Given that it affects the rest of the world in addition to countries in west and central Africa, monkeypox is a disease of worldwide public health significance. Close contact with respiratory secretions, skin sores on an infected person, or recently contaminated objects can cause human-to-human transmission. Health professionals, family members, and other close contacts of current patients are more at risk because droplet respiratory particles typically require extended face-to-face contact. Learn more: monkeypox antigen test
Single-cell sequencing technologies such as 10X Genomics, BD Phrapsody, and Illumina Hiseq have emerged that allow us to profile the genome, transcriptome and epigenomics of individual cells, unravel the heterogeneity of cell genotype, phenotype, and function within a complex cell population. Currently, single-cell sequencing technologies have been applied in a wide of life science research, including in oncology, developmental biology, microbiology, neuroscience, botany, and other fields. As an expert in the field of single-cell sequencing and analysis, Creative Biolabs provides the best and most comprehensive single-cell sequencing and analysis services. Learn more: single cell sequencing platform
Endogenously produced IFN-γ forms the basis of a tumor surveillance system against the development of primary chemically induced sarcomas. Furthermore, it plays a protective role against infection by protozoan parasites. It enhances phagocyte activity, resulting in the elimination of extracellular bacteria and protozoan parasites. Learn more: IFN-γ and γδ T Cells
Macrophages are specialized cells that rapidly recognize, engulf, and destroy pathogens or apoptotic cells. One of the fundamental features of macrophages is their high plasticity, which allows them to respond to stimuli from the complex tissue microenvironment, by changing rapidly their functional profile through polarization. Macrophages reveal specific phenotypes and functions in response to different triggers. Depending on the types of stimuli, they can polarize to M1 (pro-inflammatory) or M2 (anti-inflammatory) macrophages. Learn more: primary human macrophages
Induced pluripotent stem cells (iPSC) are cells derived from somatic cells with a number of defined factors. They served an important role in cell and tissue modeling, drug screening, and may also in future regenerative therapies. The characteristics of iPSC are similar to embryonic stem cells, thus similar methods are developed to characterize and differentiate them. With years of exploration in iPSC development, Creative Biolabs is dedicated to providing several characterization services of iPSC pluripotency for customers all over the world. Learn more: Characterization of iPSC Plutipotency
Neuronal tracers provide incomparable research tools for neuroscience, which enables visualization of neural architecture and identification of neural connections in the brain and nervous system. Neuronal tracers can be considered pathfinders in the nervous system. Learn more: neuronal tracer products
To characterize the pluripotency of iPSC, a class of defined tests can be used, and usually iPSC are characterized with the criteria applied to ES cells. Due to the differences between iPSC and ES cell expression patterns, their characteristics also not exactly the same. There are a variety of features assessed by characterization, such as cell and colony morphology, the expression of surface markers and other antigens, growth rate, the expression of pluripotency marker genes, enzyme levels, methylation statuses, as well as differentiation into somatic cell types in vitro and in vivo. Learn more: iPSC Characterization
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), also known as CD152, ALPS5, CELIAC3, GRD4, GSE, or IDDM12, is a type of CD28 homolog molecule that plays an important role in regulating T cell activation. CTLA-4 is normally present in the vesicles of cells and is then transported to the immune synapse formed between T cells and antigen-presentation cells (APCs) and inhibits further activation of T cells by blocking T cell receptors and their signaling pathways.
Macrophages are able to initiate a particular type of inflammatory response via the release of a certain pattern of cytokines. They play a major role as immunoregulatory cells. Creative Biolabs has built a highly experienced team of scientists and quality staff that have a long history in macrophage isolation and culture. Human monocyte, human alveolar, murine peritoneal cavity, murine bone marrow, murine lung, and murine adipose tissues are available for macrophage isolation and culture.
NGPs are microbial groups that meet the traditional definition of probiotics. Several microbial communities have been evaluated as NGPs. Of these, Akkermansia muciniphila, Faecalibacterium prausnitzii, Eubacterium hallii, Prevotella copri, Bacteroides spp. are the most promising. NGPs are attracting more and more interest both at academic and industrial research levels. Learn more: functional profiling for next-generation probiotics
Lipid nanoparticles (LNPs) are novel spherical vesicles with core-shell nanostructure. A typical LNP usually has a specially designed ionizable lipid component, which is positively charged at low pH (for RNA complexation) and neutral at physiological pH (reducing potential toxic effects compared with cationic liposomes). Due to their special characteristics and small size (~100 nm), LNPs could be uptake by cells via endocytosis and then release the cargo into the cytoplasm by low pH mediated endosomal escape. Thus, the LNPs possess additional advantages over the traditional lipid-based carriers such as improved nucleic acid encapsulation and transfection efficiency, better penetration capacity, and decreased cytotoxicity.
Complement factor H (CFH), a critical regulator of the complement activity, is a large glycoprotein encode by the CFH gene. In humans, five genes (CFHR1, CFHR2, CFHR3, CFHR4, and CFHR5) are found telomerically adjacent to the CFH gene and encode five different complement factor H related (CFHR) proteins. These five CFHR proteins are divided into two major groups based on their conserved domains: Group I (CFHR1, CFHR2, and CFHR5) and Group II (CFHR3 and CFHR4). Learn more: CFHR2 Protein
Creative Biolabs makes a breakthrough in guinea pig monoclonal antibody production service via hybridoma technology. Contrary to the disappointing rabbit hybridoma technology which has generally indicated low stability and productivity, our cutting-edge Guinea Pig Hybridoma technique exploits a novel source of outbreeding non-murine immune repertoire with stable productivity.
Recombinant mouse monoclonal antibody expressed in CHO binding to human IFNA1. Faralimomab is a mouse monoclonal antibody and an immunomodulator. Learn more: Faralimomab
Astrocyte is the most abundant cell type in the central nervous system (CNS), with remarkable heterogeneity in morphology and function. They are connected with CNS neurons along with other cell types to form structural and functional networks. Astrocytes rival the diversity of neurons in cellular morphologies, gene expression profiles, developmental origins, physiological properties, functions, and responses to injury and disease. Learn more: ipsc astrocytes
Calcium channels are ion channels that have selective permeability to calcium ions. Calcium is a vital signaling molecule that can mediate muscle contraction, nerve transmission, and gene expression. Disruption of normal calcium channel function causes a variety of diseases, such as inherited calcium channel diseases including neurological diseases (X-linked night blindness) and hemiplegic migraine; musculoskeletal diseases such as hypokalemic periodic paralysis and malignant hyperthermia; and cardiovascular diseases, including ventricular cardiomyopathy and familial polymorphic ventricular tachycardia. Learn more: types of calcium channels
Alzheimer's disease (AD) is the most common form of dementia, a complex neurodegenerative brain disorder characterized by the progressive impairment of cognitive functions, particularly memory, thinking, language, mood, and behavioral issues.
AD is biologically defined by the presence of β-amyloid (Abeta) -containing plaques and tau-containing neurofibrillary tangles. Abeta plaques are formed by the aggregation of beta-amyloid peptides, which are fragments of a larger protein called amyloid precursor protein (APP).
Tau tangles, on the other hand, result from the abnormal phosphorylation and aggregation of tau protein, which is normally involved in maintaining the stability of microtubules within neurons. In Alzheimer's disease, tau protein forms twisted filaments called neurofibrillary tangles.
The accumulation of beta-amyloid plaques and tau tangles initiates a cascade of events that contribute to the progressive neurodegeneration observed in AD. This includes the activation of immune cells (microglia), inflammation, impairment of synaptic connections, and disruption of various signaling pathways in the brain.
As the disease progresses, affected individuals experience a decline in cognitive abilities, memory loss, disorientation, language difficulties, and changes in behavior and personality. Learn more: Positive Regulation of Apoptotic Process
Alzheimer's disease (AD) presently occupies the topmost position among the most diagnosed neurodegenerative diseases worldwide, with the number of affected people forecasted to reach 100 million by 2050. According to the latest statistics, nearly 44 million people in the world suffer from AD or related dementia, with only one in four being diagnosed with the disease. Currently, the disease has no cure available for its treatment, except for some relief from some of the symptoms. Besides its multifactorial and heterogeneous nature, AD is also progressive, i.e., the symptoms gradually worsen with the passage of years. Multiple risk factors including genetic and environmental sources have been implicated in the emergence of AD, with advancing age being identified as the most significant among them. Learn more: screening models for alzheimer's disease
Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (Fv-IgG) is an appended IgG format, which has 2+2 antigen-binding valency. This dual variable domain IgG is generated by appending variable domains of an anti-Ad fiber knob IgG with similar domains from an anti-CEA antibody via short peptide linkers, or vice versa. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing. Learn more: Ad fiber knob CEA Fv IgG